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Class Advantages and indications Potential side effects Diuretics Beta-blockers Alpha-blockers Calcium channel blockers ACE inhibitors Salt-sensitive hypertension Large selection Selective agents preferred Young patients Clonidine useful in diabetic patients Improve renal blood flow May ameliorate cyclosporine nephrotoxicity Nifedipineisradipine preferred Native kidney hypertension Hyperuricemia Adverse impact on lipids Adverse impact on lipids (some) Relative contraindication in diabetes and vascular disease Postural hypotension (first dose) Rebound hypertension with clonidine Verapamil and diltiazem increase cyclosporine levels May precipitate renal failure Anemia with enalapril TABLE 48.

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